Vascular endothelial growth factor-A and drug level in serum and human breast milk of a lactating woman after intravitreal injection of ranibizumab: a case report.

ABSTRACT:

Background

Evidence on the excretion of anti-VEGF drugs in human breast milk was very limited. Here we investigated the level of VEGF-A protein and free drug concentration of ranibizumab in serum and breast milk following intravitreal injection of ranibizumab in a young woman suffering from branch retinal vein occlusion (BRVO).

Case presentation

A 30-year-old female, who was nursing her six-month-old son, was treated by intravitreal injection of ranibizumab (IVR) for cystoid macular edema owing to BRVO of her right eye. Serum and breast milk samples were collected before and within 4 weeks after injection. Levels of VEGF-A and free ranibizumab were evaluated in all the samples by the enzyme-linked immunosorbent assay (ELISA). Ranibizumab concentration in both serum and breas

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12900737 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature