The Immunogenicity of Human Senescent Cells Is Dependent on the Senescence Inducer and Cell Type.

ABSTRACT: Senescent cells accumulate with age and after exposure to various stresses, contributing to chronic diseases and cancer, effects largely driven by the senescence-associated secretory phenotype (SASP). Recent evidence indicates that a subset of senescent cells exhibits immunogenic properties. However, the extent to which immunogenicity depends on the cell type and the senescence inducer remains unclear. In this study, we evaluated the immunogenic properties of various human cell types induced to senesce following exposure to ionizing radiation (IR) or oncogenic RAS. Specifically, we used human dermal fibroblasts (HDF) and induced pluripotent stem cell (iPSC)-derived myoblasts (i-MB), endothelial cells (i-EC), lung progenitor cells (i-LPC), along with immune cells from autologous donors. Our

SUBMITTER: Goyer ML 

PROVIDER: S-EPMC12900895 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature