Dataset Information

From learned helplessness to motor recovery: integrating intensive neurorehabilitation in poststroke spastic paresis-clinical insights from over 10 years of practice.

ABSTRACT:

Background

Poststroke spastic paresis represents a dual pathology combining neurological impairment and secondary muscle contracture, often perpetuated by learned non-use. Current rehabilitation approaches frequently address these components separately, limiting functional recovery potential.

Methods

This perspective synthesizes over 10 years of clinical experience treating poststroke spastic paresis across European and sub-Saharan African settings, integrating constraint-induced movement therapy with progressive muscle-lengthening protocols. Clinical insights are drawn from over 300 patients treated in both resource-rich and resource-limited environments.

Results

The integrated approach demonstrates superior outcomes compared with conventional therapy, with patients showing functional improvements even years after stroke. Key success factors include intensive training protocols, systematic antagonist muscle stretching, and patient-centered motivation strategies adapted to diverse cultural contexts. European validation and African implementation confirm universal applicability.

Conclusion

Combining neuroplasticity-based interventions with muscle-targeted therapies offers a paradigm shift in poststroke rehabilitation. This approach proves effective across diverse healthcare settings, from high-technology European centers to resource-limited African hospitals, relying on intensive human intervention and evidence-based protocols.

SUBMITTER: Npochinto Moumeni I

PROVIDER: S-EPMC12901396 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

From learned helplessness to motor recovery: integrating intensive neurorehabilitation in poststroke spastic paresis-clinical insights from over 10 years of practice.

Npochinto Moumeni Ibrahim I

Frontiers in rehabilitation sciences 20260130

<h4>Background</h4>Poststroke spastic paresis represents a dual pathology combining neurological impairment and secondary muscle contracture, often perpetuated by learned non-use. Current rehabilitation approaches frequently address these components separately, limiting functional recovery potential.<h4>Methods</h4>This perspective synthesizes over 10 years of clinical experience treating poststroke spastic paresis across European and sub-Saharan African settings, integrating constraint-induced ...[more]

PMID: 41695385

Similar Datasets

Project description:Background Bovine Spastic Paresis (BSP) is a neuromuscular disorder which affects both male and female cattle. BSP is characterized by spastic contraction and overextension of the gastrocnemious muscle of one or both limbs and is associated with a scarce increase in body weight. This disease seems to be caused by an autosomal and recessive gene, with incomplete penetration, although no genes clearly involved with its onset have been so far identified. We employed cDNA microarrays to identify metabolic pathways affected by BSP in Romagnola cattle breed. Investigation of those pathways at the genome level can help to understand this disease. Results Microarray analysis of control and affected individuals resulted in 268 differentially expressed genes. These genes were subjected to KEGG pathway functional clustering analysis, revealing that they are predominantly involved in Cell Communication, Signalling Molecules and Interaction and Signal Transduction, Diseases and Nervous System classes. Significantly enriched KEGG pathway’s classes for the differentially expressed genes were calculated; interestingly, all those significantly under-expressed in the affected samples are included in Neurodegenerative Diseases. To identify genome locations possibly harbouring gene(s) involved in the disease, the chromosome distribution of the differentially expressed genes was also investigated. Conclusions The cDNA microarray we used in this study contains a brain library and, even if carrying an incomplete transcriptome representation, it has proven to be a valuable tool allowing us to add useful and new information to a poorly studied disease. By using this tool, we examined nearly 15000 transcripts and analysed gene pathways affected by the disease. Particularly, our data suggest also a defective glycinergic synaptic transmission in the development of the disease and an alteration of calcium signalling proteins. We provide data to acquire knowledge of a genetic disease for which literature still presents poor results and that could be further and specifically analysed in the next future. Moreover this study, performed in livestock, may also harbour molecular information useful for understanding human diseases.

Project description:Background Bovine Spastic Paresis (BSP) is a neuromuscular disorder which affects both male and female cattle. BSP is characterized by spastic contraction and overextension of the gastrocnemious muscle of one or both limbs and is associated with a scarce increase in body weight. This disease seems to be caused by an autosomal and recessive gene, with incomplete penetration, although no genes clearly involved with its onset have been so far identified. We employed cDNA microarrays to identify metabolic pathways affected by BSP in Romagnola cattle breed. Investigation of those pathways at the genome level can help to understand this disease. Results Microarray analysis of control and affected individuals resulted in 268 differentially expressed genes. These genes were subjected to KEGG pathway functional clustering analysis, revealing that they are predominantly involved in Cell Communication, Signalling Molecules and Interaction and Signal Transduction, Diseases and Nervous System classes. Significantly enriched KEGG pathwayM-bM-^@M-^Ys classes for the differentially expressed genes were calculated; interestingly, all those significantly under-expressed in the affected samples are included in Neurodegenerative Diseases. To identify genome locations possibly harbouring gene(s) involved in the disease, the chromosome distribution of the differentially expressed genes was also investigated. Conclusions The cDNA microarray we used in this study contains a brain library and, even if carrying an incomplete transcriptome representation, it has proven to be a valuable tool allowing us to add useful and new information to a poorly studied disease. By using this tool, we examined nearly 15000 transcripts and analysed gene pathways affected by the disease. Particularly, our data suggest also a defective glycinergic synaptic transmission in the development of the disease and an alteration of calcium signalling proteins. We provide data to acquire knowledge of a genetic disease for which literature still presents poor results and that could be further and specifically analysed in the next future. Moreover this study, performed in livestock, may also harbour molecular information useful for understanding human diseases. Samples of spinal cord from 4 affected and 4 control individuals of the Romagnola breed were collected immediately after slaughtering and later stored in RNA (Sigma-Aldrich). Dye-swaps were performed using pooled cDNA probes from the 4 control animals and the 4 affected animals.

Dataset Information

From learned helplessness to motor recovery: integrating intensive neurorehabilitation in poststroke spastic paresis-clinical insights from over 10 years of practice.

Background

Methods

Results

Conclusion

Publications

From learned helplessness to motor recovery: integrating intensive neurorehabilitation in poststroke spastic paresis-clinical insights from over 10 years of practice.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets