Discriminative compensatory activation during auditory beat perception in Parkinson's disease and multiple system atrophy.

ABSTRACT:

Introduction

Auditory beat perception (ABP) is crucial for rhythmic auditory stimulation (RAS), a therapeutic approach for neurological disorders, and particularly Parkinson's disease (PD). The mechanism is thought to be associated with increased activation of the cerebellum and motor-related regions. However, few studies have explored its effects on patients with multiple system atrophy (MSA). This study aimed to compare the compensatory mechanism of ABP in patients with PD and MSA.

Methods

Participants with PD and MSA and normal controls (NCs) were recruited from National Cheng Kung University Hospital. During task-based functional MRI (fMRI), the participants listened to rhythmic beat sounds using a boxcar paradigm. Basic characteristics and brain volumes were compared be

SUBMITTER: Chien CY 

PROVIDER: S-EPMC12901494 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature