Performance of the Self-Controlled Case Series for Drug Safety Signal Detection: A Multi-Database Study.

ABSTRACT:

Background

Differences in performance of the Self-Controlled Case Series (SCCS) for signal detection have been reported across different databases. However, there has been limited comparative analysis of performance and it remains unknown whether combinations of databases could enable more effective signal detection.

Objectives

This study aims to compare the performance of the SCCS for signal detection across several data sources, and to determine whether combinations of databases can improve SCCS performance.

Methods

We applied the SCCS to macrolides and fluoroquinolone antibiotics, in four databases: Merative MarketScan Commercial Claims and Medicare, the Clinical Practice Research Datalink (CPRD) Aurum and the Système National des Données de Santé. We developed a r

SUBMITTER: Coste A 

PROVIDER: S-EPMC12901761 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature