C1QBP Associated With Immune Infiltration Predicts Poor Prognosis in Lung Adenocarcinoma.

ABSTRACT:

Objectives

C1QBP is a multi-compartmental protein implicated in diverse cellular processes. However, its clinical predictive value, particularly its association with immune cell infiltration, in lung adenocarcinoma (LUAD) remains unelucidated. Thus, the present study aimed to comprehensively evaluate C1QBP expression patterns, prognostic significance, and its correlation with the tumor immune microenvironment (TIME) in LUAD.

Methods

We first assessed C1QBP expression levels and prognostic relevance in LUAD using multiple bioinformatics platforms. Subsequently, we analyzed the associations of C1QBP expression with immune cell infiltration and immunotherapeutic response, and identified signaling pathways linked to C1QBP expression via Gene Set Enrichment Analysis (GSEA). Final

SUBMITTER: Zhang M 

PROVIDER: S-EPMC12901909 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature