Randomized Study of Intravitreal Autologous CD34+ Stem Cells in Central Retinal Vein Occlusion (Treatment of Retinal vein occlusion Using STem cells [TRUST] Report 1): Safety and Feasibility.

ABSTRACT:

Purpose

To assess the safety and feasibility of intravitreal injection of autologous CD34+ bone marrow stem cells (BMSCs) in eyes with vision loss from central retinal vein occlusion (CRVO).

Design

Phase I/II single-center, prospective, randomized, sham-controlled, double-masked study.

Participants

Participants with CRVO of 6 to 42 months duration, best-corrected visual acuity (VA) of 20/40 to 20/400, and no concurrent retinopathy or optic neuropathy contributing to vision loss in the study eye. The exclusion criteria include any concurrent systemic condition that would alter bone marrow components.

Methods

Participants were randomized to immediate cell injection followed by sham injection at month 6 or immediate sham injection followed by cell injection at mon

SUBMITTER: Park SS 

PROVIDER: S-EPMC12902143 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature