Epidural Platelet-Rich Plasma Long-Term Outcome Is Better Than Steroid for Prolapsed Lumbar Intervertebral Discs: A Meta-Analysis of Randomized Controlled Trials.

ABSTRACT:

Background

Prolapsed lumbar intervertebral disc (IVD) is a prevalent spinal cause of low back pain associated with radicular pain. Platelet-rich plasma (PRP) has emerged as a potential alternative to epidural steroid injections. This review aimed to compare the efficacy of epidural PRP and epidural steroid injections in treating low back pain due to prolapsed lumbar IVD, assessed using a pain scale and Oswestry's disability index (ODI).

Methods

A systematic search of 4 databases (PubMed, Scopus, ScienceDirect, and Cochrane Central Register of Controlled Trials) up to July 2024 for randomized controlled trials comparing epidural PRP with steroids. Risk of Bias 2 was used for bias assessment. Pain and ODI mean differences (MDs) were calculated using RevMan v5.4. Heterogeneity

SUBMITTER: Ermawan R 

PROVIDER: S-EPMC12902210 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature