A comprehensive study on the underlying mechanisms of the lipid-lowering effects of Bao Li Er Capsule in hyperlipidemia.

ABSTRACT:

Background and aim

A traditional Mongolian formula Bao Li Er capsule (BLEC) has demonstrated excellent therapeutic effect against hyperlipidemia; however, its underlying mechanism of action remains unknown. This study aimed to investigate how BLEC lowers hyperlipidemia (HLP) in rats using network pharmacology, molecular docking, and in vivo experiments.

Methods and results

Active components from BLEC's 21 herbal ingredients were identified using the Traditional Chinese Medicine Systems Pharmacology Database and literature sources. Predicted targets were analyzed using DrugBank and GeneCards databases. Intersection genes were mapped to construct a protein-protein interaction (PPI) network via the STRING database. Molecular docking assessed the binding affinities between core

SUBMITTER: Fu X 

PROVIDER: S-EPMC12902230 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature