Taiyintiaowei-Tang ameliorates hepatic steatosis of mice fed with acute high-fat diet plus alcohol binge by blockade of NLRP3 inflammasome.

ABSTRACT:

Background and aim

Taiyintiaowei-Tang (TYTWT), a traditional Chinese Korean medicine formula, has been demonstrated to ameliorate hepatic lipid accumulation. However, the precise mechanism remains uncertain. Hepatic steatosis is classified into alcoholic and non-alcoholic forms while alcohol consumption exacerbates non-alcoholic liver disease. Considering the therapeutic effect of TYTWT on liver function, the study aimed to investigate the underlying mechanism of TYTWT on the comorbid of alcoholic and non-alcoholic hepatosteatosis.

Experimental procedure

A mouse model of comorbid alcoholic and non-alcoholic hepatosteatosis was established by feeding with high-fat diets (HFD) plus alcohol binge. In addition, to simulate the microenvironment that hepatocytes encounter, HepG2 c

SUBMITTER: Zhang ZH 

PROVIDER: S-EPMC12902233 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature