SGLT2 inhibitors and risk of atrial fibrillation recurrence after catheter ablation: A systematic review and meta-analysis of observational studies.

ABSTRACT:

Background

Sodium-glucose cotransporter 2 inhibitors (SGLT2i) exhibit potential antiarrhythmic effects, but their influence on atrial fibrillation (AF) recurrence after catheter ablation (CA) remains unclear.

Objective

This study aimed to assess the association between SGLT2i therapy and the risk of recurrent AF after CA through an updated systematic review and meta-analysis of observational studies.

Methods

A systematic search of PubMed and Scopus (inception to July 2025) identified eligible observational studies. Pooled hazard ratios for AF recurrence after CA were estimated using Mantel-Haenszel random-effects models, with heterogeneity assessed by I². The protocol was registered in PROSPERO (CRD42024620765).

Results

6 observational studies were i

SUBMITTER: Zuin M 

PROVIDER: S-EPMC12902282 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature