Clinical Emergence of <i>Bacteroides-</i>Associated Anaerobic Bacteremia Due to Drug-Resistant Non-<i>Bacteroides fragilis</i> Species: A Multicentric Retrospective Observational Study.

ABSTRACT:

Background

Bacteroides species are significant anaerobes that cause intra-abdominal infections. Recent data highlight increasing resistance, specifically to clindamycin (CLDM). However, the precise epidemiology of Bacteroides fragilis and non-fragilis remains unclear.

Methods

We retrospectively analyzed 528 obligate anaerobes that were isolated from blood cultures at 6 major Japanese hospitals between 2012 and 2022, with 102 B. fragilis and 72 non-B. fragilis isolates. Clinical characteristics and antimicrobial resistance were assessed. Drug resistance rates over time were analyzed using the Spearman rank correlation test.

Results

Compared with the B. fragilis group, non-B. fragilis group demonstrated higher resistance

SUBMITTER: Kubo R 

PROVIDER: S-EPMC12902366 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature