Myrrh ameliorates endometriosis by enhancing ER stress-related apoptotic cell death.

ABSTRACT: Endometriosis is characterized by ectopic growth of endometrial tissue causing severe abdominal pain and inflammation during disease progression. Myrrh, a resin collected from trees of genus Commiphora known for its anti-inflammatory and pain-relieving properties, has not yet been explored for endometriosis treatment. The present study utilized network pharmacology and subsequent in vitro/in vivo experiments to assess myrrh's antiendometriotic potential. In a mouse model, orally administrated myrrh significantly reduced the weight of endometriotic foci at low doses (0.7 or 3.5 mg/kg/day). Myrrh showed higher toxicity in 12Z cells compared with T-HESCs and triggered mitochondrial-associated apoptosis by altering the Bcl-2/Bax ratio. RNA sequencing and bioinformatic anal

SUBMITTER: Kim BS 

PROVIDER: S-EPMC12902740 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature