Gastric wall thickening and gastric outlet obstruction due to peritoneal metastasis in breast cancer: A case report.

ABSTRACT: Peritoneal metastasis from breast cancer is rare and diagnostically challenging. This challenge is particularly compounded in patients receiving CDK4/6 inhibitors, as their characteristic gastrointestinal adverse effects can mimic the symptoms of peritoneal carcinomatosis. A woman with hormone receptor-positive/HER2-negative metastatic breast cancer developed symptoms of functional gastric outlet obstruction (manifesting as delayed gastric emptying) 2 months after initiating palbociclib treatment. Imaging revealed diffuse and marked gastric wall thickening. Initial gastroscopic biopsies were non-diagnostic, but laparotomy confirmed peritoneal carcinomatosis, with histology and immunohistochemistry confirming metastatic breast cancer. The present case underscores the diagnostic difficulty i

SUBMITTER: He B 

PROVIDER: S-EPMC12902752 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature