Maternal diet-induced hypercholanemia alters gut microbiota and metabolome in adult female Western diet-fed offspring.

ABSTRACT: Children of mothers with intrahepatic cholestasis of pregnancy (ICP) are more likely to develop metabolic disease later in life. Using a mouse model of gestational cholestasis, we previously found that 18-week-old offspring had metabolic alterations that were exacerbated in female offspring when challenged with a Western diet (WD). Microbiota changes are emerging as a potential mechanism for developmental programming, and the maternal gut microbiota is known to be altered in pregnancy and in ICP. We hypothesized that, in our model, the offspring gut microbiota is altered by maternal gestational disease, potentially impacting future offspring metabolic health. Female mice were fed a cholic acid (CA)-supplemented diet for 1 week preceding and throughout pregnancy to mimic gestational hyperch

SUBMITTER: Ovadia C 

PROVIDER: S-EPMC12902774 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature