Exploring the anti-virulent potential of pyridine derivatives against <i>Vibrio cholerae</i>.

ABSTRACT: Vibrio cholerae, the causative agent of cholera, poses a continuous threat to global public health, especially in regions with poor sanitation. Its ability to form biofilms and rapidly acquire antimicrobial resistance (AMR) complicates therapeutic interventions. In this study, the quorum-sensing (QS) response regulator LuxO was targeted for anti-virulence therapy using a synthesized pyridine-based compound, QSI^py. Pyridine derivatives are explored as inhibitors that can target the LuxO protein, a key regulator in the QS pathway of V. cholerae. By inhibiting LuxO, these compounds reduced the virulence factor expression and biofilm formation, offering a novel antivirulence strategy without promoting resistance. Molecular docking showed that QSI^py exhibited

SUBMITTER: Sajeevan A 

PROVIDER: S-EPMC12902826 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature