Reading between the Chains: Surface Mapping and Druggable Pockets on the Biological Assemblies of DENV-2's Protein E.

ABSTRACT: Dengue is a widespread arboviral infection endemic to tropical and subtropical regions, representing a major global public health concern. Although most prevalent in South America and Asia, cases have also emerged in Europe and the United States, including instances of local transmission and fatalities. The envelope protein (protein E) is a critical structural component of the viral surface and a well-established molecular target for antiviral drug discovery, owing to its essential role in viral entry. While previous studies have primarily focused on the β-OG pocket within isolated protein E dimers, the mature virion features a complex icosahedral organization composed of protein E dimers adopting distinct assemblies, which might expose novel pockets not present in the dimeric forms, offer

SUBMITTER: Leite PTTF 

PROVIDER: S-EPMC12902848 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature