Neomycin and Clotrimazole Loaded Chitosan-Based Electrospun Wound Dressing: Development, Characterization, and Antimicrobial Properties.

ABSTRACT: This study reports a novel approach to chronic wound therapy by fabricating a dual antimicrobial electrospun wound dressing that simultaneously delivers neomycin (antibacterial) and clotrimazole (antifungal) in a poly-(vinyl alcohol) (PVA) and biocompatible chitosan (CS) PVA/CS matrix. Compared to single-drug products in use today, this new dressing mitigates polymicrobial infections characteristic of chronic wounds through controlled dual-drug release kinetics, with initial rapid neomycin (NM) release to instantaneously control bacteria and slow diffusion of clotrimazole (CZ) to provide extended antifungal coverage. Because they take longer to heal, chronic wounds with bacterial and fungal infections pose serious healthcare difficulties. The optimal polymer combination of 3% (w/v) PVA and

SUBMITTER: Piyadigama SR 

PROVIDER: S-EPMC12902851 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature