Au-PtNPs@Mn₃O₄ Nanozymes Enhance the Antitumor Effect of Photodynamic Therapy and Radiotherapy in Cervical Cancer by Modulating Tumor Hypoxia.

ABSTRACT: Photodynamic therapy (PDT) and radiotherapy (RT) are clinical treatment strategies for solid tumors. However, the uncontrolled proliferation of cancer cells leading to a hypoxic tumor microenvironment significantly reduces the efficacy. This study aimed to construct Au-PtNPs@Mn₃O₄ composite nanozymes for modulating tumor hypoxia and enhancing PDT and RT in cervical cancer. Au-PtNPs@Mn₃O₄ nanozymes were synthesized through self-assembly and electron transfer, followed by characterization and enzyme activity detection. Then, the cytotoxicity and distribution of Au-PtNPs@Mn₃O₄ nanozymes in vitro and in vivo were evaluated. After investigating the cellular uptake, the efficacy of Au-PtNPs@Mn₃O₄

SUBMITTER: Wang Z 

PROVIDER: S-EPMC12902861 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature