Carbon-11 Isotopic Radiolabeling of CP31398 and Development of a Fluorine-18 Derivative to Target Protein p53 with PET Imaging.

ABSTRACT: Mutant protein p53, a central driver of pro-oncological deregulations, is widely recognized as a biomarker of cancer aggressiveness and therapy resistance. In a personalized medicine perspective, positron emission tomography (PET) imaging of mutant p53 would be a powerful tool for patient stratification and drug development. However, to date, no PET radiotracers directly targeting mutant p53 have been reported. Inspired by the CP31398 drug, which stabilizes p53 conformation and treats tumors expressing mutant p53, we designed two novel PET radiotracers labeled with either carbon-11 by isotopic labeling or fluorine-18, namely [¹¹C]CP31398 and [¹⁸F]FG-CP31398. The nonradioactive fluorinated analogue was synthesized, as well as the two radiolabeling precurs

SUBMITTER: Beuche S 

PROVIDER: S-EPMC12902872 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature