A new class of customisable stable boronic ester assemblies.

ABSTRACT: An efficient, customisable approach for the assembly of covalent macrocycles and cages has been developed using the reaction of fused polynorbornane based bis-diols and commercially available boronic acids. The ability to customise the requisite bis-diol to various lengths and dihedral angles (here both 90° and 180°) and then combine with di or triboronic acids allows access to range of architectures. The resultant constructs were resistant to hydrolysis including 24-hour exposure to dilute solutions of either acetic or trifluoroacetic acid.

SUBMITTER: Coomber D 

PROVIDER: S-EPMC12902937 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature