Designing Bioconjugated Ti₃C₂ MXene QDs with Excellent Two-Photon Absorption Coefficients for Targeted NIR-II Imaging of Triple-Negative Breast Cancer Cells.

ABSTRACT: Since NIR-II (1000-1700 nm) imaging offers deeper tissue penetration, improved resolution, and higher signal-to-background ratios, development of two-photon excitation NIR-II probes is very important for next-generation bioimaging. Triple-negative breast cancer (TNBC) is inherently aggressive, with poor prognosis and therapeutic resistance, where two-photon diagnostics using the NIR-II probe are very important for effective disease monitoring and management. Herein, we report on the design of strong quantum-confined bioconjugated Ti₃C₂ MXene quantum dots (MXene QDs)-based NIR-II probe with a very large two-photon absorption (TPA) coefficient (β), which can be used for targeted two-photon fluorescence (TPF) imaging of live cancer cells. Our finding reveals that due to

SUBMITTER: Rai S 

PROVIDER: S-EPMC12902965 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature