Design and Evaluation of Quinoline-derived Fluorophores for Labeling Amyloid Beta 1-42 in Alzheimer's Disease.

ABSTRACT: Amyloid beta (Aβ) is a key biomarker in Alzheimer's disease, driving the formation of senile plaques that contribute to neuronal death within a complex etiology. Typically, most treatments begin at advanced stages, when irreversible brain atrophy has already occurred; therefore, early diagnosis is essential for effective intervention. Several probes based on the conventional donor-π-acceptor (D-π-A) structural motif have been developed as diagnostic tools, yet few have reached clinical trials. Alternatively, quinoline-based fluorescent compounds with push-pull structures and aggregation-induced emission properties show enhanced fluorescence in the aggregated state due to restricted intramolecular motion (RIM). Accordingly, four quinoline derivatives2QnCN, 3QnCN, 3QnB, and 4QnBBwere synth

SUBMITTER: Sanchez-Mendoza AV 

PROVIDER: S-EPMC12903005 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature