Loading Density Influences the Tumor Cell Targeting and Signaling Inhibition Capabilities of Antibody Nanoconjugates.

ABSTRACT: Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype and accounts for up to 20% of all breast cancers. Since conventional chemotherapy and radiotherapy are ineffective against TNBC, nanoparticle-based medicines are being investigated as a potentially superior treatment option. Of such platforms, antibody-nanoparticle conjugates have been shown to precisely target diseased cells through selective antigen binding and to regulate oncogenic cellular signaling by blocking ligand activation of the targeted receptor. For example, silica core-gold shell "nanoshells" (NS) conjugated to Frizzled7 (FZD7) antibodies can preferentially bind TNBC cells to suppress Wnt signaling and inhibit disease progression. To improve understanding of antibody nanoconjugate structure/func

SUBMITTER: Kramarenko GC 

PROVIDER: S-EPMC12903012 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature