Synergistic Effects in Matrix-Embedded Alloy Nanoclusters: Advanced Type-I Photosensitizers for Theranostics.

ABSTRACT: A combination of biomedical imaging and photodynamic therapy (PDT) in a single nanomaterial would be a breakthrough in nanomedicine. However, devising a single photosensitizer capable of efficient PDT without requiring an external oxygen source under typically hypoxic tumor conditions, combined with high photostability, biocompatibility, and renal clearance, remains a challenge. Atomically precise ultrasmall (<2 nm) gold nanoclusters (AuNCs) are emerging as potential multifunctional biomedicines, encompassing imaging, diagnosis, and therapy in a single nanoplatform. Herein, we report bioderived cellulose nanocrystal-supported gold nanoclusters (CNC-AuNCs) with selective mono or multiheteroatom (Ag, Pd, and Pt) substitution at the core of the nanoclusters. The replacement of one or more gol

SUBMITTER: Hosseiniyan N 

PROVIDER: S-EPMC12903107 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature