Recyclable Hydrotalcite-Supported Copper Catalysts for Green and Regioselective Click Synthesis of 1,2,3-Triazoles.

ABSTRACT: This work reports a sustainable and highly efficient catalytic system based on cuprous oxide nanoparticles supported on hydrotalcite (Cu ₂ O@LDH-01) for the regioselective synthesis of 1,2,3-triazoles via copper-catalyzed azide-alkyne cycloaddition (CuAAC) in aqueous media. The catalyst was comprehensively characterized by XRD, FTIR, BET, TGA, and STEM-EDX analyses, confirming the successful incorporation and uniform dispersion of the Cu-(I) species within the layered double hydroxide structure. Under mild and additive-free conditions, Cu ₂ O@LDH-01 afforded quantitative conversions in water within only 5 min under ultrasound irradiation, emphasizing the crucial role of acoustic cavitation in enhancing mass transfer and cataly

SUBMITTER: de Carvalho GSG 

PROVIDER: S-EPMC12903169 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature