Double Salts and Racemate in Mefloquine-Ibuprofen and Mefloquine-Ketoprofen Systems. A Structural and Thermochemical Analysis.

ABSTRACT: The formation of salts remains a highly sought-after yet unpredictable strategy for resolving chiral drugs. Using a drug-drug approach, we have investigated the crystallization behavior of Mefloquine (Mf), a racemic antimalarial drug, in combination with enantiopure (S)-ibuprofen and (S)-ketoprofen, as well as their racemic forms. Double salts and racemates have been obtained and characterized by single-crystal and powder X-ray diffraction, Hirshfeld surface analysis, thermal analysis (DSC and TGA), and solubility measurements. Structural analysis reveals that the formation of double salts often follows a pattern similar to the packing and supramolecular motifs found in the corresponding racemates. For the ketoprofen systems, the double salt and racemate have been found to be isostructural

SUBMITTER: Martins JB 

PROVIDER: S-EPMC12903187 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature