Apathy, effort-based decisions and brain integrity in Alzheimer's and Parkinson's diseases.

ABSTRACT: Apathy, or loss of motivation, is a prominent syndrome accompanying both Alzheimer's and Parkinson's disease, in addition to other disorders. One approach to understanding motivational loss is to examine the processes underlying goal-directed behaviour. Weighing up rewarding outcomes against the effort costs required to obtain them - effort-based decision-making - is a core computation when deciding to act for outcomes. Whilst a growing body of evidence points to disruption of this computation in people with apathy, which underlying decision parameters drive this disruption, their neural associations, and whether these would generalise or differ across brain disorders has not been examined. People with amnestic mild cognitive impairment and probable Alzheimer's disease (aMCI/pAD) (n=37), P

SUBMITTER: Morris LA 

PROVIDER: S-EPMC12903196 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature