CTSB-positive tumor-associated macrophages shape prognosis and therapeutic response in lung adenocarcinoma.

ABSTRACT:

Background

Lung adenocarcinoma (LUAD) remains a major clinical challenge in assessment of clinical outcomes and therapeutic response. Although tumor-associated macrophages (TAMs) are known as crucial regulators of tumor progression, their heterogeneity and prognostic relevance in LUAD have not been fully elucidated.

Methods

The heterogeneity of TAMs was detected by integration analyses of single-cell data and spatial transcriptome data. The CTSB⁺ TAM-related signature (CTRS) was developed by machine learning algorithms across four LUAD datasets. Multi-omics analysis and functional experiments were applied to uncover the potential role and mechanism of CTSB⁺ TAMs in LUAD.

Results

Single-cell analysis identified CTSB⁺ TAM as a crucial player in LUA

SUBMITTER: Zhu C 

PROVIDER: S-EPMC12903197 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature