Molecular features of prenylated (iso)flavonoids from Fabaceae in relation to their potential NorA inhibition in <i>Staphylococcus aureus</i>.

ABSTRACT:

Background

The overexpression of the NorA efflux pump is known to be an important factor in the antimicrobial resistance mechanism of Staphylococcus aureus. Therefore, NorA inhibition can help disarm this pathogen and tackle antimicrobial resistance. In this study, we aim to unravel the molecular properties of prenylated (iso)flavonoids from Fabaceae as potential NorA inhibitors and to propose leading compounds for future research.

Methods

A collection of 37 prenylated isoflavonoids and flavonoids (obtained by purification, chemically synthesized, or commercially purchased), collectively referred to as (iso)flavonoids, was evaluated for its activity against norA-overexpressing Staphylococcus aureus using the checkerboard assay with ciprofloxacin (NorA su

SUBMITTER: Irianti MI 

PROVIDER: S-EPMC12903279 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature