Triglyceride-glucose-related indices and cardiovascular outcomes in individuals with pre-frailty or frailty: insights from a prospective cohort analysis using UK Biobank data.

ABSTRACT:

Background

Triglyceride-glucose (TyG)-related indices, which have emerged as promising prognostic markers in multiple vulnerable populations, are closely linked to the incidence and progression of cardiovascular disease (CVD). Nevertheless, their associations with CVD morbidity and mortality, as well as the underlying biological mechanisms, remain unclear in pre-frail or frail populations. We aimed to evaluate the associations of multiple TyG-related indices with incident CVD and cardiovascular mortality among pre-frail or frail individuals, and to explore potential mediating biological pathways.

Methods

In this prospective cohort analysis using UK Biobank data, 136,004 pre-frail or frail individuals [median age (interquartile range): 57.0 (49.0, 63.0) years; 54.4% female] w

SUBMITTER: Tian Z 

PROVIDER: S-EPMC12903331 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature