Notch-1 suppressed vascular dementia via modulating AMPK/mTOR/TFEB/YAP signaling induced ferroptosis.

ABSTRACT:

Objective

The aim of this study is to clarify the molecular mechanism by which Notch-1 prevents vascular dementia (VD) by preventing ferroptosis caused by the AMPK/mTOR/TFEB/YAP pathway.

Methods

Thirty male SD rats were used in the in vivo tests. They were split into three groups at random: the sham group, the model group, and the model + Notch1-OE group. The water maze test was used to evaluate the rats' spatial learning and memory capacities. Western blotting was done to look at protein expression in hippocampus tissues, and Nissl staining was utilized to see changes in Nissl bodies. Purchased hippocampus cells were used in in vitro tests, and they were split up into six groups and exposed to various stimuli. Fe²⁺ levels were assessed, protein expression was obs

SUBMITTER: Zhu L 

PROVIDER: S-EPMC12903360 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature