Prefoldin 3 promotes the turnover of WRKY70 and FHY3 to modulate UV-B-induced hypocotyl growth inhibition in Arabidopsis thaliana.

ABSTRACT: Ultraviolet-B (UV-B) radiation, a pervasive light stimulus, profoundly influences plant hypocotyl growth through intricate signaling pathways. Although the core UV-B signaling components have been identified, the precise regulatory mechanisms remain elusive. Here, we identify prefoldin 3 (PFD3), an α subunit of the PFD complex, as a novel negative regulator of UV-B-induced hypocotyl growth inhibition in Arabidopsis thaliana. Upon UV-B exposure, PFD3 accumulates and promotes the turnover of WRKY DNA-BINDING PROTEIN 70 (WRKY70) and FAR-RED ELONGATED HYPOCOTYL 3 (FHY3), thereby attenuating their transcriptional activities toward ELONGATED HYPOCOTYL 5 (HY5)/PACLOBUTRAZOL RESISTANCE1 (PRE1) and CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1), respectively. These findings delineate two regulatory modules

SUBMITTER: Song Y 

PROVIDER: S-EPMC12903397 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature