Molecular surveillance of GI-19 lineage infectious bronchitis virus in China: divergent evolution and efficacy assessment of QXL87 vaccine against heterologous clades.

ABSTRACT:

Background

Infectious bronchitis is a highly contagious acute disease in chickens caused by the infectious bronchitis virus (IBV). The GI-19 lineage of IBV has been shown to undergo continuous evolution, with increasing variance in antigenicity and pathogenicity in China. The aim of this study was to assess the efficacy of the only registered QX vaccine (i.e., QXL87) in China against diverse GI-19 clades.

Results

A total of 1503 S1 sequences from China were identified as belonging to the IBV GI-19 based on phylogenetic analysis, including sequences from GenBank and clinical samples sequenced by our team (Key Laboratory of Animal Infectious Diseases of Ministry of Agriculture, China) from 2018 to 2022. Within the GI-19 lineage, five clades were identified and QXL87 vaccine be

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12903415 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature