Associations of nutritional risk, pre-treatment malnutrition, and cachexia with mortality, local recurrence, and metastasis in head and neck cancer: a five-year prospective cohort study.

ABSTRACT:

Background

Malnutrition is a recognized risk factor for reduced survival in patients with head and neck cancer (HNC). However, evidence remains limited regarding whether, and to what extent, pre-treatment nutritional parameters contribute to local recurrence and metastasis. So, the aim was to estimate the association between pre-treatment nutritional parameters and these outcomes such as mortality, local recurrence, and metastasis over a five-year follow-up in patients with HNC, and to assess the prognostic validity of the nutritional parameters.

Methods

A prospective cohort study was conducted with 84 HNC patients treated at a reference outpatient clinic, followed for up to five years after treatment initiation. Nutritional status was assessed using the Patient-Generated Su

SUBMITTER: Lima EDNS 

PROVIDER: S-EPMC12903417 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature