A Modular Synthetic Strategy toward Fast-Growing Poly(amide-carbosilane) Dendrimers Based on Click Chemistry and Organic Solvent Nanofiltration.

ABSTRACT: Dendrimers, constituting a prominent class of monodisperse and multivalent macromolecular compounds with outstanding properties, are characterized by regular and highly branched three-dimensional architectures and well-defined chemical structures. Within each structural type, the skeletal diversity is typically limited to the range of generations. Here, we introduce a novel modular synthetic strategy enabling an increase in the diversity of the dendrimer interior while maintaining its chemical nature. Resulting poly-(amide-carbosilane) (PAMCAS) dendrimers can be fine-tuned within one generation in terms of size, number, and density of end groups, as well as interior free volume. Using a tetravalent core and two building blocksdendritic wedges with branching degrees 3 and 6we demonstrate

SUBMITTER: Edr A 

PROVIDER: S-EPMC12903430 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature