Sepsis induces long-term reprogramming of human HSPCs and drives myeloid dysregulation in sepsis survivors.

ABSTRACT:

Background

Sepsis is a life-threatening condition characterised by an overwhelming immune response and high fatality. While most research has focused on its acute phase, many sepsis survivors remain immunologically weakened leaving them susceptible to serious complications from even mild infections. The mechanisms underlying this prolonged immune dysregulation remain unclear, limiting effective interventions. Here, we analysed whether sepsis induced long-term "training" in hematopoietic stem and progenitor cells (HSPCs), imprinting changes that persist in their myeloid progeny.

Results

Peripheral blood analysis of 8 sepsis survivors, 12 patients with septic shock, and 10 healthy donors revealed a significant expansion of CD38 + progenitors in survivors, with increased megaka

SUBMITTER: De Zuani M 

PROVIDER: S-EPMC12903497 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature