The TP53-LGALS4 axis modulates the tumor immune microenvironment and synergizes with anti PD-L1 therapy in colorectal cancer.

ABSTRACT:

Background

The role of galectin-4 (LGALS4) in colorectal cancer (CRC) progression and the tumor immune microenvironment (TIME) is poorly understood.

Methods

Through analysis of single-cell profiling data from various colon tissues, this work identifies tumor suppressor genes critically involved in CRC development. The impact of LGALS4 on CT26 cell growth was evaluated through a combination of in vitro and in vivo experiments. The potential mechanisms regulating LGALS4 expression and LGALS4 regulatory biological functions were investigated using different analytical and detection assays. In vivo experiments evaluated the synergistic anti-tumor effect of LGALS4 overexpression and PDL1 neutralizing antibody.

Results

This study revealed that the expression of LGALS4 was s

SUBMITTER: Zhang F 

PROVIDER: S-EPMC12903506 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature