The plasma nanoDSF denaturation profiles predict the presence of breast cancer.

ABSTRACT:

Background

Breast cancer (BC) is a major problem of public health in western countries. The long-term survival improved thanks to therapeutic progresses and mass screening. Mass screening is based on mammography but displays limitations. Efforts are ongoing to develop accurate and minimally invasive tools for early BC detection. Analysis of liquid biopsies is a promising option, among which the ones based on thermal denaturation profiling provide a "thermodynamic signature" of disease through analysis of plasma protein denaturation profiles. We recently developed a major technical breakthrough of differential scanning calorimetry by switching to nanoDSF (Differential Scanning Fluorimetry), more easily transferrable in clinical routine. Here, we applied it for the first time to samp

SUBMITTER: Guerin M 

PROVIDER: S-EPMC12903520 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature