Association between the triglyceride glucose index:Chinese visceral adiposity index (TyG-CVAI) and new-onset cardiovascular disease in middle-aged and older adults-insights from the China Health and Retirement Longitudinal Study (CHARLS).

ABSTRACT:

Background

Insulin resistance and visceral adiposity are established pathophysiological drivers of cardiovascular disease (CVD). The triglyceride‒glucose (TyG) index and the Chinese visceral adiposity index (CVAI) are respective indicators of these conditions. However, the association of their combination, the TyG-CVAI, with the risk of new-onset CVD in the general population remains unclear. This study aimed to investigate this relationship using data from a large national cohort.

Methods

This prospective study included participants in the China Health and Retirement Longitudinal Study (CHARLS) who lacked CVD at baseline. The TyG-CVAI was calculated and used to categorize participants into quartiles. The primary endpoint was the incidence of new-onset CVD. Kaplan‒Meier anal

SUBMITTER: Zheng W 

PROVIDER: S-EPMC12903522 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature