<i>Panax notoginseng</i> Saponins Ameliorate High-Fat Diet-Induced Liver Injury via Mechanisms Involving TLR4-Mediated Signaling and Lipid Metabolism.

ABSTRACT: Panax notoginseng saponins (PNS), the primary bioactive constituents derived from the traditional herb Panax notoginseng, have been used in nutritional supplements. However, their molecular mechanisms against hyperlipidemia-induced liver injury remain to be fully elucidated. In this study, supplementation with PNS (200 mg/kg diet) for 12 weeks significantly ameliorated high-fat diet (HFD)-induced liver injury in C57BL/6J mice, as evidenced by improved serum lipid profiles and attenuated hepatic oxidative stress and inflammation. Lipidomics analysis indicated that PNS administration restored hepatic lipid homeostasis, particularly by normalizing dysregulated triglycerides. Mechanistically, PNS markedly suppressed the activation of key inflammatory signaling pathways, including

SUBMITTER: Li R 

PROVIDER: S-EPMC12903550 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature