Integrative multi-omics analysis reveals IFIT3⁺ macrophage-associated ISG20 as a prognostic biomarker and elucidates underlying tumor-suppressive mechanisms in ovarian cancer.

ABSTRACT: Ovarian cancer (OC) remains the most lethal gynecologic malignancy, with the regulatory role of innate immunity in its progression and treatment poorly understood. This study provides a thorough characterization of OC immune microenvironment by combining multi-omics data. Our findings show innate immune signals in myeloid cells are central to communication within tumor microenvironment. Analysis of innate immune scores revealed IFIT3⁺macrophages exhibit the highest innate immune scores. By triggering inflammatory reactions, IFN-α interferon pathways, IFIT3⁺macrophages are essential for the onset of OC. Using high-dimensional weighted gene co-expression network analysis algorithm, we identified 25 genes associated with IFIT3⁺macrophages and developed a progn

SUBMITTER: Li X 

PROVIDER: S-EPMC12903577 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature