Inference of SARS-CoV-2 exposure biomarkers using large-scale T-cell repertoire profiling.

ABSTRACT:

Background

The COVID-19 pandemic offers a powerful opportunity to develop methods for monitoring the spread of infectious diseases based on their signatures in population immunity. Adaptive immune receptor repertoire sequencing (AIRR-seq) has become the method of choice for identifying T cell receptor (TCR) biomarkers encoding pathogen specificity and immunological memory. AIRR-seq can detect imprints of past and ongoing infections and facilitate the study of individual responses to SARS-CoV-2, as shown in many recent studies.

Methods

The new batch effect correction method allowed us to use data from different batches together, as well as combine the analysis for data obtained using different protocols. Proper standardization of AIRR-seq batches, access to human leukocyte an

SUBMITTER: Vlasova EK 

PROVIDER: S-EPMC12903587 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature