Core-shell microneedles with MMP/pH-triggered release for periodontitis bone repair.

ABSTRACT: Periodontitis is a localized inflammatory condition triggered by periodontal pathogens and marked by uneven loss of alveolar bone. The clash between the persistent inflammatory environment and requirement for bone regeneration complicates the treatment of periodontitis. To address this issue, we developed a core-shell microneedles drug delivery system responsive to both high matrix metalloproteinase (MMP) expression and a local acidic microenvironment, which are the pathological characteristics of periodontal lesions. This system utilizes a dual mechanism of MMP hydrolysis and pH triggering to achieve precise spatiotemporal release of therapeutic molecules and multimodal synergistic treatment. The microneedles system utilizes a layered core-shell design: the outer shell is loaded with glyc

SUBMITTER: Liu J 

PROVIDER: S-EPMC12903683 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature