Brain radiotherapy combined with immune checkpoint inhibitors and chemotherapy as first-line treatment for advanced non-small cell lung cancer with brain metastases: a retrospective study.

ABSTRACT:

Background

Brain metastasis (BM) remains a major therapeutic challenge in non-small cell lung cancer (NSCLC) without actionable driver mutations. Radiotherapy combined with immune checkpoint inhibitors (ICIs) may enhance intracranial control through synergistic immune activation. This study evaluated the efficacy of radiotherapy plus ICI and explored prognostic factors influencing outcomes in patients with NSCLC-BM.

Methods

We retrospectively analyzed 116 patients with measurable, driver-negative NSCLC-BM treated between June 2019 and December 2024. Patients were divided into two groups: Radiotherapy combined with ICI plus chemotherapy (RT + ICI, n = 56) and ICI plus chemotherapy (ICI, n = 60). Intracranial and systemic objective response rates (iORR, sORR) and progression-f

SUBMITTER: Wu W 

PROVIDER: S-EPMC12903702 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature