Genomic characterization of a virulent multidrug-resistant Salmonella enterica serovar Enteritidis strain isolated from meat rabbits (Oryctolagus cuniculus) in China.

ABSTRACT:

Background

Salmonella enterica serovar Enteritidis (SE) is a major foodborne pathogen. While poultry is a known source, the threat from other livestock like rabbits (Oryctolagus cuniculus) is not well studied. This work investigates a highly virulent, multidrug-resistant (MDR) SE isolate, SE JL228, from a lethal rabbit farm outbreak in China in 2018. The objective of this study was to elucidate the genetic characteristics, antimicrobial resistance determinants, metal tolerance mechanisms, and virulence potential of a rabbit-derived isolate. This study provides important insights that advance our understanding of public and animal health risks.

Results

This isolate exhibited resistance to 13 antibiotics within 8 antimicrobial categories as well as to silver (Ag⁺),

SUBMITTER: Zhang R 

PROVIDER: S-EPMC12903752 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature