Distinct medial temporal volumetric signatures in extra-medial temporal lobe lesional epilepsy.

ABSTRACT:

Objective

To quantify amygdala and hippocampal volumetric asymmetries in patients with drug-resistant epilepsy (DRE) and extra-medial temporal lesions (EMTLs) and to assess the prevalence of structural alterations relative to drug-resistant temporal lobe epilepsy (TLE), extratemporal lobe epilepsy (ETLE), and healthy individuals.

Methods

Retrospective cross-sectional study of 298 participants evaluated at the NIH Clinical Center (2004-2023), including 252 patients with focal DRE and 46 healthy volunteers. Of the DRE cohort, 63 had lateralized EMTL (48 left, 15 right). High-resolution brain MRIs were segmented and analyzed to obtain normalized amygdala and hippocampal volumes. An asymmetry index (AI) assessed directionality, and absolute AI measured magnitude. Atrophy and hyp

SUBMITTER: Serlin Y 

PROVIDER: S-EPMC12903800 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature