Cardiovascular morbidity following epilepsy: A nationwide retrospective cohort study in South Korea.

ABSTRACT:

Objective

This study evaluated the long-term risk of major cardiovascular diseases (CVDs) in patients with epilepsy using a nationwide cohort, aiming to address critical gaps in population-based evidence on brain-heart interactions.

Methods

Data from the Korean National Health Insurance Service (2002-2013) were analyzed. For each cardiovascular outcome, an independent matched cohort was constructed, comprising 1740 to 3164 patients with newly diagnosed epilepsy and corresponding 10-fold matched controls. The primary outcomes included six CVDs: hypertension (HTN), ischemic heart disease (IHD), cardiac arrhythmia (CA), heart failure (HF), atherosclerosis (AS), and peripheral artery disease (PAD). Incidence rate ratios (IRRs) and adjusted hazard ratios (aHRs) were calculated us

SUBMITTER: Bae Y 

PROVIDER: S-EPMC12903816 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature