Thiol-Free Sulfenylation Redefined: A Single-Atom Transfer Pathway to Symmetrical Di(hetero)arylthioethers via B(C₆F₅)₃ Catalysis.

ABSTRACT: Diarylated thioethers are privileged scaffolds found across pharmaceuticals, functional materials, and molecular electronics. Conventional approaches to these motifs, typically via C-H functionalization or C-X cross-coupling with thiophenols, disulfides, thiosulfonates, and related sulfenylating agents, remain hampered by foul odors, instability, air- and moisture- sensitivity, tedious synthesis, and poor selectivity, often producing undesired byproducts. In contrast, the few strategies that employ elemental sulfur for symmetrical thioether synthesis are largely confined to copper catalysis and lack generality. Therefore, a straightforward and sustainable route to symmetrical thioethers from readily accessible, bench-stable sulfenylating agents with broad substrate compatibility is highly

SUBMITTER: Pramanik M 

PROVIDER: S-EPMC12903844 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature