Identification of antidepressant response-related changes to DNA methylation and gene expression.

ABSTRACT:

Background

Major depressive disorder (MDD) is a debilitating condition that is commonly treated with antidepressants. However, many people do not respond to treatment, and the molecular mechanisms underlying antidepressant response remain poorly understood. Baseline DNA methylation differences have been observed between individuals who respond to treatment compared to those who do not respond; however, little is known regarding DNA methylation changes that occur during treatment or how they may relate to clinical response.

Methods

We assessed peripheral levels of DNA methylation and gene expression at baseline and after 8 weeks of treatment in 154 individuals with MDD who were treated with escitalopram or desvenlafaxine, using the Infinium MethylationEPIC Beadchip and RNA se

SUBMITTER: Fiori LM 

PROVIDER: S-EPMC12903956 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature